Dade | Nissui | Wako | Eiken | KDK | IRC | Kainos | Sysmex

Eiken Chemical Co., Ltd.

1-33-8 Hongo, Bunkyo-ku, Tokyo 113-8408, Japan
Contact: Mr. Shuichi Takahashi, International Business Division
5-26-20 Oji, Kita-ku, Tokyo 114-0002, Japan
Tel: +81-3-3913-6493, Fax: +81-3-3913-6555
E-mail: webmaster@eiken.co.jp, Web: http://www.eiken.co.jp

1. Serum Amyloid A Protein (SAA), a Rapid Acute Phase Reactant

  1. Product: LZ Test 'Eiken' SAA
  2. Principle:
    Anti SAA coated latex agglutination photometric immunoassay. The reagent can be applied to autoanalyzers for Clinical Chemistries (Hitachi, Olympus etc.).
  3. Features:
    SAA is a sensitive and rapid acute phase reactant for the monitoring of inflammatory diseases and assessing the prognosis in secondary amyloidosis. Serum SAA levels in patients with inflammatory diseases, mostly correlate with that of CRP, conventional acute phase reactant, however, SAA levels show higher and may respond more rapidly. Especially, the response of serum SAA in patients with immunosuppressive therapy with cyclosporin, prednisolone, in which serum CRP may be suppressed, still occurs. Thus, SAA may be useful for diagnosis of inflammatory diseases.
  4. Related products: LX reagent 'Eiken' SAA, LZ Test 'Eiken' CRP
  5. Reference:
    (1) T. Yamada, et al.: Ann Clin Biochem, 30:72-76, 1993
    (2) T. Nakayama, et al.: Clin. Chem., 39(2):293-297, 1993
    (3) M. Casl, et al.: Nephron, 70:112-113, 1995

2. Latex Photometric Immunoassay Reagent for Basic Fetoprotein (BFP)

  1. Product: LX reagent 'Eiken' BFP
  2. Principle:
    Anti BFP monoclonal antibody coated latex photometric immunoassay. The reagent can be applied to a fully automatic immunochemical analyzer LX (Eiken chemical Co., Ltd.).
  3. Features:
    BFP is a fetoprotein found in the intestines, serum and brain tissue of human fetuses by Ishii and is a basic protein with a molecular weight of 55kD migrating to gammaglobulin fraction in the electrophoresis. Serum BFP has been widely used as a broader spectrum tumor marker. Recently, the presence of BFP in the urine has been confirmed and its clinical significance has been evaluated. At present, the measurement of BFP in the urine is considered to be highly useful for the diagnosis of urothelial cancer, especially bladder cancer.
  4. Reference:
    (1) M. Ishii: Scand. J. Immunol., 8(suppl.8):611-620, 1978
    (2) T. Kigure, et al.: J. Jpn. Soci. Cancer Ther., 26(5):991-995, 1991

3. ELISA Kit for Serum Pepsinogen I (PG I) and Pepsinogen II (PG II)

  1. Product: E-Plate 'Eiken' Pepsinogen I and E-Plate 'Eiken' Pepsinogen II
  2. Principle:
    The test method is based on the solid phase 2 step sandwich enzyme immunoassay method using 96 wells microplate coated with anti Pepsinogen I and anti Pepsinogen II as solid-phase, respectively.
  3. Features:
    Pepsinogen(PG) is an inactive zymogen of pepsin, a proteolytic enzyme found in gastric secretions. It is immunologically classified into two types, pepsinogen I (PG I) and pepsinogen II (PG II). Since the serum levels of PG I and PG II reflect primarily the number of chief cells and accessory cells in gastric fundus, it is thought that measurements of serum PG I and PG II, as well as the ratio of PG I/PG II may be useful in the evaluation of the degree of atrophic gastritis, diagnosis of peptic ulcer disease and the assessment of gastric acidity. It is also known that lesions with a high degree of atrophy are considered to be associated with a higher incidence of stomach cancer,therefore, the measurements of PG I and PG II may be useful as a screening tool in populations at high risk for stomach cancer.
  4. Reference:
    (1) K. Miki: Jpn. J. Med. Pharm. Sci., 37(4):1013-1021, 1997
    (2) K. Miki: Jpn. J. Gastroenterological Mass Survey, 32(4):19-30, 1994
    (3) M. Samloff: Gastroenterology, 82:26-33, 1982

4. ELISA Kit for Serum Bisphenol A (BPA)

  1. Product : BPA ELISA 'Eiken'
  2. Principle:
    This method is an enzyme-linked immunosorbent assay (ELISA) using the second antibody solid-phase method, based on the competitive method.
  3. Features :
    4, 4'-Isopropylidenediphenol (Bisphenol A : BPA) is used as a starting material for epoxy and polycarbonate resins, and as a stabilizer for polyvinyl chloride resin. Polycarbonate is widely used in polycarbonate baby bottles and in the epoxy resin coating of the lid and polyethylene terephthalate (PET), and it is thought that BPA has a close connection with endocrine disruption. It has been shown that a large number of determinations in possible, the cost of the reagents is lower, and the assay procedure is simpler than with other methods, such as GC-MS and HPLC. As a means of evaluating safety to humans, the proposed method can contribute to the determination of BPA.
  4. Reference :
    (1) F. S. Vom Saal, et al. : J. Anim. Sci., 67 : 1824-1840, 1989
    (2) K. L. Howdeshell, et al. : Nature, 6755 : 763-764, 1999
    (3) H. Ohkuma, et al. : Analyst, 127(1) : 93-97, 2002

- products -