HEMOGLOBINOPATHIES May 14, 1999

George C. Hoffman M. D.

E-mail address : geohoffman@ewol.com

These are a large group of disorders that range from entirely benign to incompatible with life.

They are all inherited disorders.
They are the commonest inherited disorders.

The most widespread, such as the sickling disorders and thalassemias, persist because they combat malaria.

These lectures will consist of the following sections:

Lecture 1.

a. Normal hemoglobins and their genes
b. Types of abnormalities
c. Laboratory studies

Lecture 2.

a. Case studies
　　1. The thalassemias
　　2. The structural abnormalities
　　3. Hereditary persistence of fetal hemoglobin (HPFH)
　　4. Combinations
　　5. Newborn screening
b. Summary